MRC-Holland’s objective is to provide easy-to-use, high quality tools for genetic analysis at a price that laboratories in most parts of the world can afford.

MRC-Holland operates in close collaboration with scientists around the world to constantly develop novel MLPA applications and improve existing ones. Results obtained with MLPA probe sets have been described in hundreds of scientific publications. Researchers are encouraged to contact us to suggest new MLPA applications or to provide feedback on current probe sets.

Corporate social responsibility is very important to MRC-Holland. Part of our profit is invested by our MRC-Holland Foundation in scientific (medical) research and spent on community projects in less privileged countries.

The knowledge of the genetic origins of disease has increased tremendously in the last 20 years, offering the potential to truly improve the diagnosis and treatment of patients. Not only can DNA and RNA analysis shed light on hereditary conditions, but it may also advance patient care in cancer.

The translation of knowledge into products suitable for routine diagnostics – affordable, fast and easy-to-interpret— requires dedicated, simple-to-use genetic tests. The informative output of such assays should be restricted to genes that are known to be directly involved in a specific disorder.

MRC-Holland continually develops and improves its MLPA products, aiming to bring high quality genetic analysis within reach of as many patients as possible, all around the globe.
new products
Hypophosphatasia (HPP)
Various cancer types
P480-WHS & Achondroplasia
Wolf Hirschhorn Syndrome, Achondroplasia
Meningioma, Coffin-Siris syndrome
improved products
Spinal muscular atrophy (SMA)
Cytochrome P450
PTEN hamartoma tumor syndrome, Cowden syndrome, Bannayan-Riley-Ruvalcaba syndrome, PTEN-related proteus syndrome, Proteus-like syndrome; (Tumour analysis for research use only)
Lynch syndrome; MUTYH-associated polyposis (MAP)
Juvenile polyposis syndrome (JPS)
Propionic acidemia
Susceptibility to breast cancer; Susceptibility to other cancer types
Thyroid dysgenesis
P098-Wilson disease
Wilson disease
Beta-thalassemia; Persistence of foetal haemoglobin, hereditary (HPFH); Sickle cell anaemia (SCA); Sickle cell disease (SCD)
Mismatch repair genes (MMR)
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