Introducing SALSA® Melt Assay
for Spinal Muscular Atrophy (SMA)

SALSA® MC002 SMA Newborn Screen (CE)

Holiday Closure
Dear Customer,

We would like to thank you for your trust in our company and our products. Thanks to your support and valued feedback we have been able to launch many new and improved products in 2018. We would like to wish you a wonderful holiday season and a healthy 2019!

MRC-Holland will be closed from 25 December through 1 January.

 Shipping DateOrder Deadline
Last shipment 2018:Mon 17 DecemberTue 11 December
First shipment 2019:Mon 7 JanuaryThu 20 December

Best wishes & season's greetings,

MRC-Holland

MLPA
MLPA® is the gold standard for DNA copy number quantification and is used to study both hereditary disorders and tumours. MLPA can also be applied to investigate the methylation status of DNA sequences. MRC-Holland, the inventor and manufacturer of MLPA, offers 400 different MLPA panels. Popular applications include:
  • Predisposition to Cancer
  • Neuromuscular Disorders
  • Intellectual Disability
  • Solid Tumours

News

▷ Launch of SALSA Melt Assay: SALSA MC002 SMA Newborn Screen
The SALSA MC002 SMA Newborn Screen is the latest product from MRC Holland, and the only product targeted at newborn population screening for a disorder. The assay is simple to use and runs on standard equipment allowing easy implementation and streamlining SMA screening. For more information visit our launch page, or see our press release.

▷ New protocol versions available
As of 17 April 2018, new versions of the MLPA General Protocol and the MS-MLPA General Protocol have been published online. You can find the new versions on the MLPA Protocols page. Both protocols have been reorganized and rewritten. The most important changes can be found in the document history on page 2 of each protocol.

▷ MRC-Holland to supply HhaI enzyme
Important news for MS-MLPA users: MRC-Holland has launched its own restriction enzyme SALSA HhaI. The HhaI enzyme – an essential component of MS-MLPA reactions – was developed to ensure that every aspect of MLPA, from start to result interpretation, is of the highest standards.

A free vial of SALSA HhaI enzyme (item number: SMR51) will be included with all orders containing an MS-MLPA probemix from 3 April until 31 December 2018 (extended). More information can be found here.

MLPA Workshops
MLPA workshop figure

To increase your understanding of MLPA, MRC-Holland continues to organize one-day MLPA workshops. During the theoretical and practical sessions, participants learn how to get the most out of their MLPA data from setting up the experiment to the result interpretation and troubleshooting.

Check out our destinations for upcoming workshops on our Support Portal!

Support Portal
Do you have a technical question about MLPA or Coffalyser.Net? Visit our Support Portal for support-related content such as:
  • troubleshooting guidance;
  • knowledgebase articles (FAQ);
  • instruction videos;
  • e-learning modules;
  • manuals & other downloads.

You can also contact us directly from the portal, and optionally view and manage your correspondence with our Technical Support department.

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new products
P484-ALPL
Hypophosphatasia (HPP)
P474-CD274-PDCD1LG2-JAK2
Various cancer types
P480-WHS & Achondroplasia
Wolf Hirschhorn Syndrome, Achondroplasia
P478-SMARCE1
Meningioma, Coffin-Siris syndrome
improved products
P021-SMA
Spinal muscular atrophy (SMA)
P128-CYP450
Cytochrome P450
P225-PTEN
PTEN hamartoma tumor syndrome, Cowden syndrome, Bannayan-Riley-Ruvalcaba syndrome, PTEN-related proteus syndrome, Proteus-like syndrome; (Tumour analysis for research use only)
P072-MSH6-MUTYH
Lynch syndrome; MUTYH-associated polyposis (MAP)
P158-JPS
Juvenile polyposis syndrome (JPS)
P278-PCCA-PCCB
Propionic acidemia
P190-CHEK2
Susceptibility to breast cancer; Susceptibility to other cancer types
P319-Thyroid
Thyroid dysgenesis
P098-Wilson disease
Wilson disease
P102-HBB
Beta-thalassemia; Persistence of foetal haemoglobin, hereditary (HPFH); Sickle cell anaemia (SCA); Sickle cell disease (SCD)
ME011-MMR
Mismatch repair genes (MMR)
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