MLPA® is the gold standard for DNA copy number quantification and is used to study both hereditary disorders and tumours. MLPA can also be applied to investigate the methylation status of DNA sequences. MRC-Holland, the inventor and manufacturer of MLPA, offers 400 different MLPA panels. Popular applications include:
  • Predisposition to Cancer
  • Neuromuscular Disorders
  • Intellectual Disability
  • Solid Tumours

MLPA workshops
MLPA workshop figure

To increase your understanding of MLPA, MRC-Holland continues to organize one-day MLPA workshops. During the theoretical and practical sessions, participants learn how to get the most out of their MLPA data from setting up the experiment to the result interpretation and troubleshooting.


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new products
P461-DIS
Deafness Infertility Syndrome (DIS); non-syndromic hearing loss
P338-GBA
Gaucher disease
P298-BRAF-HRAS-KRAS-NRAS
Various tumour types
P463-MRKH
Mayer-Rokitansky-Küster-Hauser Syndrome
P454-CGD
Chronic Granulomatous Disease
improved products
P160-STS
Steroid Sulfatase gene (STS)
P297-Microdeletion-2
Microdeletion syndromes
P243-SERPING1 - F12
Hereditary angioedema (HAE)
P017-MEN1
Multiple endocrine neoplasia
P414-MDS
Myelodysplastic syndrome
P311-CHD
Congenital Heart Disease (CHD)
P214-COL2A1
Skeletal disorders, Achondrogenesis, Chondrodysplasia, Early onset familial Osteoarthritis, SED congenital, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome, Spondyloepimetaphyseal
P090-BRCA2
Breast cancer, hereditary
P045-BRCA2/CHEK2
Breast cancer, hereditary
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