Predisposition to Cancer
You may also be interested in our brochure MLPA for Predisposition to Cancer (link opens in a new window).

Product NameApplicationRegion
ME011-MMRimproved Mismatch repair genes (MMR) MLH1 3p22.2; MSH2 2p21; MSH6 2p16.3; PMS2 7p22.1; EPCAM 2p21; BRAF V600E
ME024-9p21 Tumours, Cutaneous melanoma 9p21: CDKN2A, CDKN2B, and flanking genes
P002-BRCA1CECOMAIL Breast and ovarian cancer, hereditary (HBOC) BRCA1 17q21.31
P003-MLH1/MSH2CEMAIL Lynch syndrome MLH1 3p22.2; MSH2 2p21
P008-PMS2CE Lynch syndrome; Constitutional MMR-deficiency syndrome (CMMR-D) PMS2 7p22.1
P016-VHLCEMAIL Von Hippel-Lindau syndrome VHL 3p25.3
P017-MEN1CE Multiple endocrine neoplasia type 1 (MEN1) MEN1 11q13.1
P031-FANCA mix 1 Fanconi anemia (FA) FANCA 16q24.3
P032-FANCA mix 2 Fanconi anemia (FA) FANCA 16q24.3
P041-ATM-1CEMAIL Ataxia-telangiectasia (AT); Predisposition to develop cancer, hereditary ATM 11q22.3
P042-ATM-2CEMAIL Ataxia-telangiectasia (AT); Predisposition to develop cancer, hereditary ATM 11q22.3
P043-APCCEMAIL Adenomatous polyposis, familial (FAP); MUTYH-associated polyposis (MAP); Polyposis syndrome, hereditary mixed (HMPS1) APC 5q22.2; MUTYH 1p34.1; GREM1 15q13.3
P044-NF2 Neurofibromatosis type 2 (NF2) NF2 22q12.2
P045-BRCA2/CHEK2CECOMAIL Breast and ovarian cancer, hereditary (HBOC); Susceptibility to breast cancer; Susceptibility to other cancer types BRCA2 13q13.1; CHEK2 22q12.1
P046-TSC2 Tuberous sclerosis complex (TSC) TSC2 16p13.3
P047-RB1 Retinoblastoma (RB) RB1 13q14.2
P056-TP53CE Li-Fraumeni syndrome (LFS); (Tumour analysis for research use only) TP53 17p13.1
P057-FANCD2-PALB2 Fanconi anemia (FA) FANCD2 3p25.3; PALB2 16p12.2
P067-PTCH1 Gorlin syndrome; 9q22.3 Microdeletion PTCH1 9q22.3
P072-MSH6-MUTYHCEimproved Lynch syndrome; MUTYH-associated polyposis (MAP) MSH6 2p16.3; MUTYH 1p34.1; EPCAM 2p21
P077-BRCA2 ConfirmationCEMA Breast and ovarian cancer, hereditary (HBOC) (confirmation of P045/P090) BRCA2 13q13.1
P081-NF1 mix 1CEMAIL Neurofibromatosis type 1 (NF1) NF1 17q11.2
P082-NF1 mix 2CEMAIL Neurofibromatosis type 1 (NF1) NF1 17q11.2
P083-CDH1CEMAIL Diffuse gastric cancer, hereditary CDH1 16q22.1
P087-BRCA1 ConfirmationCE Breast and ovarian cancer, hereditary (HBOC) (confirmation of P002) BRCA1 17q21.31
P090-BRCA2CECOMAIL Breast and ovarian cancer, hereditary (HBOC) BRCA2 13q13.1
P101-STK11CEIL Peutz-Jeghers syndrome (PJS) STK11 19p13.3
P113-FANCB Fanconi anemia complementation group B FANCB Xp22
P118-WT1 Wilms tumours, WAGR, Denys-Drash, Frasier syndrome. WT1 11p13
P122-NF1-area Neurofibromatosis NF1 17q11.2
P124-TSC1CE Tuberous sclerosis complex (TSC) TSC1 9q34.13
P158-JPSimproved Juvenile polyposis syndrome (JPS) BMPR1A 10q23, SMAD4 18q21, PTEN 10q23
P190-CHEK2CEimproved Susceptibility to breast cancer; Susceptibility to other cancer types CHEK2 22q12.1; ATM 11q22.3; TP53 17p13.1
P215-EXT Multiple Osteochondromas EXT1 8q24, EXT2 11p11
P225-PTENCEimproved PTEN hamartoma tumor syndrome, Cowden syndrome, Bannayan-Riley-Ruvalcaba syndrome, PTEN-related proteus syndrome, Proteus-like syndrome; (Tumour analysis for research use only) PTEN 10q23.31
P226-SDHCE Paragangliomas-Pheochromocytoma syndrome, hereditary (PGL/PCC) SDHD 11q23.1; SDHB 1p36.1; SDHC 1q23.3; SDHAF1 19q13.12; SDHAF2 11q12.2
P239-BRCA1 region Breast cancer BRCA1 region
P240-BRIP1/CHEK1 Hereditary predisposition to Cancer BRIP1 17q22, CHEK1 11q22
P244-AIP-MEN1-CDKN1B Multiple endocrine neoplasia (MEN) AIP 11q13, MEN1 11q13, CDKN1B 12p13
P248-MLH1-MSH2 Confirmation Lynch syndrome MLH1 3p22.2; MSH2 2p21
P258-SMARCB1 Rhabdoid tumors SMARCB1 22q11.2
P260-PALB2-RAD50-RAD51C-RAD51DCE Susceptibility to breast and ovarian cancer; Susceptibility to other cancer types; Fanconi-anemia type N RAD50 5q31.1; PALB2 16p12.1; RAD51D 17q12; RAD51C 17q22
P295-SPRED1 SPRED1 SPRED1 15q14
P308-MET Papillary renal carcinoma, various cancers MET 7q31, PTEN 10q23.31, LRRK2 12q12
P337-TSC2 Tuberous sclerosis TSC2 gene, 16p13.3
P378-MUTYHCEMA MUTYH-associated polyposis (MAP); Polyposis syndrome, hereditary mixed (HMPS1) MUTYH 1p34.1; SCG5 15q13.3; GREM1 15q13.3
P417-BAP1 Melanocytic tumours, mesothelioma BAP1, 3p21.1
P419-CDKN2A/2B-CDK4 Familial melanoma CDKN2A, CDKN2B, CDK4, MITF E318K
P429-SDHA-MAX Paraganglioma and pheochromocytoma 5p15.3 and 14q23.3
P437-Familial MDS-AML Familial MDS-AML RUNX1, CEBPA, GATA2, TERT, TERC
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